Workflow Methods

extract_tables()

Extract tables from a given genome scale metabolic model(GEM) of ".mat" format

signature2gene()

Map metabolic signatures to enzyme-coding genes

enrichment()

Enrichment analysis

hypGEM_to_excel()

Writes the enrichment results out to an Excel workbook

hypGEM_filter()

Filter the enrichment results by fdr value, and optionally sub-selects result columns

refmet_convert()

Convert metabolite names to RefMet via Metabolomics Workbench

Plot Methods

enrichment_plot()

Enrichment analysis visualization

rctbls()

Reactable table for hypeR_GEM_enrichment object

visNet()

Title Query and plot the sub-graph

ggempty()

An empty ggplot

sankey_plot()

Create a 3-layer Sankey diagram (Metabolites → MSETs → GSETs)

Data Objects

Human_GEM_tables

Undirectional mapping tables of Human GEM

Human_GEM_tables_di

Directional mapping tables of Human GEM

Mouse_GEM_tables

Undirectional mapping tables of Mouse GEM

Mouse_GEM_tables_di

Directional mapping tables of Mouse GEM

Rat_GEM_tables

Undirectional mapping tables of Rat GEM

Rat_GEM_tables_di

Directional mapping tables of Rat GEM

Zebrafish_GEM_tables

Undirectional mapping tables of Zebrafish GEM

Zebrafish_GEM_tables_di

Directional mapping tables of Zebrafish GEM

Worm_GEM_tables

Undirectional mapping tables of Worm GEM

Worm_GEM_tables_di

Directional mapping tables of Worm GEM

COVID_serum

Metabolite signatures of COVID obtained from Human serum

COVID_urine

Metabolite signatures of COVID obtained from Human urine

reactome

Reactome genesets

Human_ig

Network of Human GEM

hypeR_object_NECS

Example hypeR-GEM object (NECS)

metabolon_msets_list

Metabolon-based metabolite set list (NECS-derived)

gsets_list

Enriched gene set list (Hallmark, KEGG, Reactome)