Workflow Methods |
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Extract tables from a given genome scale metabolic model(GEM) of ".mat" format |
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Map metabolic signatures to enzyme-coding genes |
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Enrichment analysis |
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Writes the enrichment results out to an Excel workbook |
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Filter the enrichment results by fdr value, and optionally sub-selects result columns |
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Convert metabolite names to RefMet via Metabolomics Workbench |
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Plot Methods |
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Enrichment analysis visualization |
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Reactable table for hypeR_GEM_enrichment object |
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Title Query and plot the sub-graph |
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An empty ggplot |
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Create a 3-layer Sankey diagram (Metabolites → MSETs → GSETs) |
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Data Objects |
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Undirectional mapping tables of Human GEM |
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Directional mapping tables of Human GEM |
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Undirectional mapping tables of Mouse GEM |
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Directional mapping tables of Mouse GEM |
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Undirectional mapping tables of Rat GEM |
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Directional mapping tables of Rat GEM |
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Undirectional mapping tables of Zebrafish GEM |
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Directional mapping tables of Zebrafish GEM |
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Undirectional mapping tables of Worm GEM |
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Directional mapping tables of Worm GEM |
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Metabolite signatures of COVID obtained from Human serum |
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Metabolite signatures of COVID obtained from Human urine |
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Reactome genesets |
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Network of Human GEM |
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Example hypeR-GEM object (NECS) |
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Metabolon-based metabolite set list (NECS-derived) |
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Enriched gene set list (Hallmark, KEGG, Reactome) |
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