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Transcriptomic signature: Myc haploinsufficient mouse liver (Myc(+/-), version 4)

Source: R/omic_signature_4.R
omic_signature_4.Rd

This dataset contains a transcriptomic signature derived from liver tissue of Myc haploinsufficient (Myc(+/-)) mice compared to wild-type (WT) controls. The data represent differential gene expression results obtained using an array-based transcriptomic platform. This dataset corresponds to version 4 of the Myc_reduce_mice_liver_24m signature series.

Usage

omic_signature_4

Format

A list (or Signature object) with the following components:

Metadata

A named list containing experimental and analytical metadata:

  • adj_p_cutoff: Adjusted p-value cutoff used for differential expression (0.05).

  • assay_type: Type of assay used: "transcriptomics".

  • description: Study description: Myc haploinsufficient (Myc(+/-)) mice.

  • direction_type: Indicates that both up- and down-regulated genes are included ("bi-directional").

  • phenotype: Phenotype: "Myc_reduce".

  • sample_type: Tissue: liver.

  • organism: Species: Mus musculus.

  • platform: Transcriptomics by array.

  • PMID: Publication identifier: 25619689.

  • year: Publication year: 2015.

  • keywords: Keywords: Myc, KO, longevity.

  • score_cutoff: Signature score cutoff: 5.

  • signature_name: Signature name: "Myc_reduce_mice_liver_24m_v4".

  • covariates: Covariates used: none.

  • animal_strain: Animal strain: C57BL/6.

Signature

A summary of sample groups in the study:

  • MYC Reduce: 5 samples (Myc(+/-) mice).

  • WT: 10 samples (wild-type mice).

DifferentialExpressionData

A numeric data frame or matrix of dimension 884 x 10 containing differential expression statistics for 884 genes across 10 variables (e.g., logFC, AveExpr, t, P.Value, adj.P.Val, etc.).

Source

Derived from PMID: 25619689.

Details

The Myc_reduce_mice_liver_24m_v4 signature represents age-associated differential gene expression in liver tissue from Myc haploinsufficient mice compared to wild-type controls. Reduced Myc dosage has been linked to extended lifespan and altered metabolic pathways in murine models.